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Bariatric Surgery

Preoperative liking and wanting for sweet beverages as predictors of body weight loss after Roux-en-Y gastric bypass and sleeve gastrectomy

International Journal of Obesity volume 44, pages 1350–1359 (2020)Cite this article

Subjects

Abstract

Background/objectives

Patients who receive Roux-en-Y gastric bypass (RYGB) lose more weight than those who receive vertical sleeve gastrectomy (VSG). RYGB and VSG alter hedonic responses to sweet flavor, but whether baseline differences in hedonic responses modulate weight loss after RYGB or VSG remains untested.

Participants/methods

Male and female candidates (n = 66) for RYGB or VSG were recruited and tested for their subjective liking and wanting ratings of sucrose solutions and flavored beverages sweetened with aspartame. Participants were classified by unsupervised hierarchical clustering for their liking and wanting ratings of sucrose and aspartame. Participant liking ratings were also used in a supervised classification using pre-established categories of liking ratings (liker, disliker, and inverted u-shape). Effects of categories obtained from unsupervised or supervised classification on body weight loss and their interaction with surgery type were analyzed separately at 3 and 12 months after surgery using linear models corrected for sex and age.

Results

RYGB participants lost more body weight compared with VSG participants at 3 and 12 months after surgery (P < 0.001 for both time points). Unsupervised clustering analysis identified clusters corresponding to high and low wanting or liking ratings for sucrose or aspartame. RYGB participants in high-wanting clusters based on sucrose, but not aspartame, lost more weight than VSG at both 3 (P = 0.01) and 12 months (P = 0.03), yielding a significant cluster by surgery interaction. Categories based on supervised classification using liking ratings for sucrose or aspartame showed no significant effects on body weight loss between RYGB and VSG participants.

Conclusions

Classification of patients into high/low-wanting ratings for sucrose before surgery can predict differential body weight loss after RYGB or VSG in adults and could be used to advise on surgery type.

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References

  1. Chang SH, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA. The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003–2012. JAMA Surg. 2014;149:275–87.

    Article  PubMed  PubMed Central  Google Scholar 

  2. King WC, Hinerman AS, Belle SH, Wahed AS, Courcoulas AP. Comparison of the performance of common measures of weight regain after bariatric surgery for association with clinical outcomes. JAMA. 2018;320:1560–9.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Osland E, Yunus RM, Khan S, Memon B, Memon MA. Weight loss outcomes in laparoscopic vertical sleeve gastrectomy (LVSG) versus laparoscopic Roux-en-Y gastric bypass (LRYGB) procedures: a meta-analysis and systematic review of randomized controlled trials. Surg laparosc Endosc Percutan Tech. 2017;27:8–18.

    Article  PubMed  Google Scholar 

  4. Celio AC, Wu Q, Kasten KR, Manwaring ML, Pories WJ, Spaniolas K. Comparative effectiveness of Roux-en-Y gastric bypass and sleeve gastrectomy in super obese patients. Surg Endosc. 2017;31:317–23.

    Article  PubMed  Google Scholar 

  5. Rondelli F, Bugiantella W, Vedovati MC, Mariani E, Balzarotti Canger RC, Federici S, et al. Laparoscopic gastric bypass versus laparoscopic sleeve gastrectomy: a retrospective multicenter comparison between early and long-term post-operative outcomes. Int J Surg. 2017;37:36–41.

    Article  PubMed  Google Scholar 

  6. Panagiotou OA, Markozannes G, Adam GP, Kowalski R, Gazula A, Di M, et al. Comparative effectiveness and safety of bariatric procedures in medicare-eligible patients: a systematic review. JAMA Surg. 2018;153:e183326.

    Article  PubMed  Google Scholar 

  7. Ahmed B, King WC, Gourash W, Belle SH, Hinerman A, Pomp A, et al. Long-term weight change and health outcomes for sleeve gastrectomy (SG) and matched Roux-en-Y gastric bypass (RYGB) participants in the Longitudinal Assessment of Bariatric Surgery (LABS) study. Surgery. 2018;164:774–83.

    Article  PubMed  Google Scholar 

  8. Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A. et al. Important role of the GLP-1 axis for glucose homeostasis after bariatric surgery. Cell Rep. 2019;26:1399–1408.e6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Behary P, Miras AD. Food preferences and underlying mechanisms after bariatric surgery. Proc Nutr Soc. 2015;74:419–25.

    Article  PubMed  Google Scholar 

  10. Miras AD, le Roux CW. Mechanisms underlying weight loss after bariatric surgery. Nat Rev Gastroenterol Hepatol. 2013;10:575–84.

    Article  PubMed  Google Scholar 

  11. Lauti M, Kularatna M, Hill AG, MacCormick AD. Weight regain following sleeve gastrectomy-a systematic review. Obes Surg. 2016;26:1326–34.

    Article  PubMed  Google Scholar 

  12. Al-Khyatt W, Ryall R, Leeder P, Ahmed J, Awad S. Predictors of inadequate weight loss after laparoscopic gastric bypass for morbid obesity. Obes Surg. 2017;27:1446–52.

    Article  PubMed  Google Scholar 

  13. Scozzari G, Passera R, Benvenga R, Toppino M, Morino M. Age as a long-term prognostic factor in bariatric surgery. Ann Surg. 2012;256:724–8. discussion728-9

    Article  PubMed  Google Scholar 

  14. Andersen JR, Aadland E, Nilsen RM, Vage V. Predictors of weight loss are different in men and women after sleeve gastrectomy. Obesity Surg. 2014;24:594–8.

    Article  Google Scholar 

  15. Parri A, Benaiges D, Schroder H, Izquierdo-Pulido M, Ramon J, Villatoro M, et al. Preoperative predictors of weight loss at 4 years following bariatric surgery. Nutrition Clin Pract. 2015;30:420–4.

    Article  Google Scholar 

  16. Baldridge AS, Pacheco JA, Aufox SA, Kim KY, Silverstein JC, Denham W, et al. Factors associated with long-term weight loss following bariatric surgery using 2 methods for repeated measures analysis. Am J Epidemiol. 2015;182:235–43.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Generali I, De Panfilis C. Personality traits and weight loss surgery outcome. Curr Obes Rep. 2018;7:227–34.

    Article  PubMed  Google Scholar 

  18. Marek RJ, Tarescavage AM, Ben-Porath YS, Ashton K, Merrell Rish J, Heinberg LJ. Using presurgical psychological testing to predict 1-year appointment adherence and weight loss in bariatric surgery patients: predictive validity and methodological considerations. Surg Obes Relat Dis. 2015;11:1171–81.

    Article  PubMed  Google Scholar 

  19. Wakayama L, Nameth K, Adler S, Safer DL. Replication and extension of dietary adherence as a predictor of suboptimal weight-loss outcomes in postbariatric patients. Surg Obes Relat Dis. 2019;15:91–6.

    Article  PubMed  Google Scholar 

  20. Sarwer DB, Wadden TA, Moore RH, Baker AW, Gibbons LM, Raper SE, et al. Preoperative eating behavior, postoperative dietary adherence, and weight loss after gastric bypass surgery. Surg Obes Relat Dis. 2008;4:640–6.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Ahmed K, Penney N, Darzi A, Purkayastha S. Taste changes after bariatric surgery: a systematic review. Obes Surg. 2018;28:3321–32.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Kittrell H, Graber W, Mariani E, Czaja K, Hajnal A, Di Lorenzo PM. Taste and odor preferences following Roux-en-Y surgery in humans. PLoS ONE. 2018;13:e0199508.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  23. Hansen TT, Jakobsen TA, Nielsen MS, Sjodin A, Le Roux CW, Schmidt JB. Hedonic changes in food choices following Roux-en-Y gastric bypass. Obes Surg. 2016;26:1946–55.

    Article  PubMed  Google Scholar 

  24. Miras AD, Jackson RN, Jackson SN, Goldstone AP, Olbers T, Hackenberg T, et al. Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task. Am J Clin Nutr. 2012;96:467–73.

    Article  CAS  PubMed  Google Scholar 

  25. Sudan R, Sudan R, Lyden E, Thompson JS. Food cravings and food consumption after Roux-en-Y gastric bypass versus cholecystectomy. Surg Obes Relat Dis. 2017;13:220–6.

    Article  PubMed  Google Scholar 

  26. Nielsen MS, Christensen BJ, Ritz C, Rasmussen S, Hansen TT, Bredie WLP, et al. Roux-En-Y gastric bypass and sleeve gastrectomy does not affect food preferences when assessed by an ad libitum buffet meal. Obes Surg. 2017;27:2599–605.

    Article  PubMed  Google Scholar 

  27. Sugerman HJ, Londrey GL, Kellum JM, Wolf L, Liszka T, Engle KM, et al. Weight loss with vertical banded gastroplasty and Roux-Y gastric bypass for morbid obesity with selective versus random assignment. Am J Surg. 1989;157:93–102.

    Article  CAS  PubMed  Google Scholar 

  28. Sugerman HJ, Starkey JV, Birkenhauer R. A randomized prospective trial of gastric bypass versus vertical banded gastroplasty for morbid obesity and their effects on sweets versus non-sweets eaters. Ann Surg. 1987;205:613–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Herpertz S, Kielmann R, Wolf AM, Hebebrand J, Senf W. Do psychosocial variables predict weight loss or mental health after obesity surgery? A systematic review. Obes Res. 2004;12:1554–69.

    Article  CAS  PubMed  Google Scholar 

  30. Fox B, Chen E, Suzo A, Jolles S, Greenberg JA, Campos GM, et al. Dietary and psych predictors of weight loss after gastric bypass. J Surg Res. 2015;197:283–90.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Berridge KC, Ho CY, Richard JM, DiFeliceantonio AG. The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res. 2010;1350:43–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Finlayson G, King N, Blundell JE. Liking vs. wanting food: importance for human appetite control and weight regulation. Neurosci Biobehav Rev. 2007;31:987–1002.

    Article  PubMed  Google Scholar 

  33. Berridge KC. Motivation concepts in behavioral neuroscience. Physiol Behav. 2004;81:179–209.

    Article  CAS  PubMed  Google Scholar 

  34. Thompson DA, Moskowitz HR, Campbell RG. Effects of body weight and food intake on pleasantness ratings for a sweet stimulus. J Appl Physiol. 1976;41:77–83.

    Article  CAS  PubMed  Google Scholar 

  35. Iatridi V, Hayes J, Yeomans M. Reconsidering the classification of sweet taste liker phenotypes: a methodological review. Food Qual Prefer. 2019;72:56–76.

    Article  Google Scholar 

  36. Garbutt JC, Osborne M, Gallop R, Barkenbus J, Grace K, Cody M, et al. Sweet liking phenotype, alcohol craving and response to naltrexone treatment in alcohol dependence. Alcohol Alcohol. 2009;44:293–300.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Garbutt JC, Kampov-Polevoy AB, Kalka-Juhl LS, Gallop RJ. Association of the sweet-liking phenotype and craving for alcohol with the response to naltrexone treatment in alcohol dependence: a randomized clinical trial. JAMA Psychiatry. 2016;73:1056–63.

    Article  PubMed  Google Scholar 

  38. Iatridi V, Hayes JE, Yeomans MR. Quantifying sweet taste liker phenotypes: time for some consistency in the classification criteria. Nutrients. 2019;11:1–24.

    Article  CAS  Google Scholar 

  39. Sclafani A, Ackroff K. Glucose- and fructose-conditioned flavor preferences in rats: taste versus postingestive conditioning. Physiol Behav. 1994;56:399–405.

    Article  CAS  PubMed  Google Scholar 

  40. Klein DA, Schebendach JS, Devlin MJ, Smith GP, Walsh BT. Intake, sweetness and liking during modified sham feeding of sucrose solutions. Physiol Behav. 2006;87:602–6.

    Article  CAS  PubMed  Google Scholar 

  41. Klein DA, Schebendach JE, Brown AJ, Smith GP, Walsh BT. Modified sham feeding of sweet solutions in women with and without bulimia nervosa. Physio Behav. 2009;96:44–50.

    Article  CAS  Google Scholar 

  42. Hogenkamp PS, Shechter A, St-Onge MP, Sclafani A, Kissileff HR. A sipometer for measuring motivation to consume and reward value of foods and beverages in humans: description and proof of principle. Physiol Behav. 2017;171:216–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Garneau N, Nuessle T, Mendelsber B, Shepard S, Tucker R. Sweet liker status in children and adults: Consequences for beverage intake in adults. Food Qual Prefer. 2018;65:175–80.

    Article  PubMed  Google Scholar 

  44. Kim J, Prescott J, Kim K. Emotional responses to sweet foods according to sweet liker status. Food Qual Prefer. 2017;59:1–7.

    Article  Google Scholar 

  45. Berry DA. Logarithmic transformations in ANOVA. Biometrics. 1987;43:439–56.

    Article  CAS  PubMed  Google Scholar 

  46. Measures of difference for compositional data and hierarchical clustering methods. Proc IAMG. 1998;98:526–31.

  47. Park P, Manjourides J, Bonetti M, Pagano M. A permutation test for determining significance of clusters with applications to spatial and gene expression data. Comput Stat Data Anal. 2009;53:4290–4300.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Bray GA, Barry RE, Benfield JR, Castelnuovo-Tedesco P, Rodin J. Intestinal bypass surgery for obesity decreases food intake and taste preferences. TAm J Clin Nutr. 1976;29:779–83.

    Article  CAS  Google Scholar 

  49. Mathes CM, Spector AC. Food selection and taste changes in humans after Roux-en-Y gastric bypass surgery: a direct-measures approach. Physiol Behav. 2012;107:476–83.

    Article  CAS  PubMed  Google Scholar 

  50. Ochner CN, Kwok Y, Conceicao E, Pantazatos SP, Puma LM, Carnell S, et al. Selective reduction in neural responses to high calorie foods following gastric bypass surgery. Ann Surg. 2011;253:502–7.

    Article  PubMed  Google Scholar 

  51. Ochner CN, Stice E, Hutchins E, Afifi L, Geliebter A, Hirsch J, et al. Relation between changes in neural responsivity and reductions in desire to eat high-calorie foods following gastric bypass surgery. Neuroscience. 2012;209:128–35.

    Article  CAS  PubMed  Google Scholar 

  52. Bueter M, Miras AD, Chichger H, Fenske W, Ghatei MA, Bloom SR, et al. Alterations of sucrose preference after Roux-en-Y gastric bypass. Physiol Behav. 2011;104:709–21.

    Article  CAS  PubMed  Google Scholar 

  53. Pliner P, Fleming AS. Food intake, body weight, and sweetness preferences over the menstrual cycle in humans. Physiol Behav. 1983;30:663–6.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by NIH 1R01DK108643 (HR Kissileff, PI), FONDECYT Regular 1150274 (Perez-Leighton) and the New York Nutrition Obesity Research Center (DK-26687). Aspartame was a gift from Ajinomoto Co., Inc., Tokyo, Japan

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Authors and Affiliations

  1. Department of Physiology, School of Biological Sciences, Pontificia Universidad Católica, Santiago, Chile

    Claudio E. Perez-Leighton

  2. Department of Medicine, New York Nutrition Obesity Research Center and Division of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA

    Jeon D. Hamm, Ari Shechter, Shoran Tamura, Blandine Laferrère,  Xavier Pi-Sunyer & Harry R. Kissileff

  3. Mt. Sinai St. Luke’s Hospital, New York, NY, USA

    Jeon D. Hamm, Jeanine Albu & Harry R. Kissileff

  4. NutriSci Incorporated, Mt. Kisco, NY, USA

    Danielle Greenberg

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Perez-Leighton, C.E., Hamm, J.D., Shechter, A. et al. Preoperative liking and wanting for sweet beverages as predictors of body weight loss after Roux-en-Y gastric bypass and sleeve gastrectomy. Int J Obes 44, 1350–1359 (2020). https://doi.org/10.1038/s41366-019-0474-1

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