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Genetics and Epigenetics

Thanks for opening an overdue discussion on GWAS of BMI: a reply to Prof. Speakman et al.

International Journal of Obesityvolume 43pages217218 (2019) | Download Citation

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  1. 1.

    Speakman JR, Loos RJF, O’Rahilly SO, Hirschhorn JN, Allison DB. GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. Int J Obesity. 2018.

  2. 2.

    Müller MJ, Geisler C, Blundell J, Dulloo A, Schutz Y, Krawczak M, et al. The case of GWAS of obesity: Does body weight control play the rules? Int J Obesity. 2018.

  3. 3.

    Speakman JR. The evolution of body fatness: trading off disease and predation risk. J Exp Biol. 2018;221(Pt Suppl 1):pii: jeb167254.

  4. 4.

    Leibel RL. Molecular physiology of weight regulation in mice and humans. Int J Obes. 2008;32(Suppl 7):S98–S108.

  5. 5.

    Ferrannini E, Rosenbaum M, Leibel RL. The threshold shift paradigm of obesity: evidence from surgically induced weight loss. Am J Clin Nutr. 2014;100:996–1002.

  6. 6.

    Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378:804–14.

  7. 7.

    Swinburn B, Kraak V, Rutter H, Vandevijvere S, Lobstein T, Sacks G, et al. Strengthening of accountability systems to create healthy food environments and reduce global obesity. Lancet. 2015;385:2534–2545.

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Author information


  1. Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel, Kiel, Germany

    • Manfred J. Müller
    • , Corinna Geisler
    •  & Anja Bosy-Westphal
  2. Institut für Medizinische Informatik und Statistik, Christian-Albrechts-Universität zu Kiel, Kiel, Germany

    • Michael Krawczak
  3. Pennington Biomedical Research Center, Baton Rouge, LA, USA

    • Steven Heymsfield
  4. Institute de Physiology, University of Lausanne, Lausanne, Switzerland

    • Yves Schutz
  5. Department of Medicine, Division of Physiology, University of Fribourg, Fribourg, Switzerland

    • Abdul Dulloo
  6. Institute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, UK

    • John Blundell


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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Manfred J. Müller.

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