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Clinical Research

Prenatal education of overweight or obese pregnant women to prevent childhood overweight (the ETOIG study): an open-label, randomized controlled trial

International Journal of Obesityvolume 43pages362373 (2019) | Download Citation




We aimed to evaluate whether pre and perinatal education of pregnant women would reduce childhood overweight.


Four French centers included women at ≤21 gestational weeks (GWs) with body mass index (BMI) >25 kg/m2 before pregnancy. Patients were randomized to a control group (routine care including at least one dietary visit) or an intervention group (2 individuals (26 and 30 GW) and 4 group sessions (21, 28, 35 GW, 2 months postpartum)) aimed at educating the future mother regarding infant and maternal nutrition. The primary objective was to reduce post-natal excessive weight gain in the infant from birth to 2 years (NCT00804765). This project was funded by a grant from the National Programme for Hospital Research (PHRC-2007 French Ministry of Health).


We included 275 women (BMI: 32.5 kg/m2). The rate of post-natal excessive weight gain was similar in the intervention (n = 132) and control (n = 136) groups by intention to treat (ITT: 59.1% vs 60.3% respectively, p = 0.84) in available data (AD, n = 206) and by per-protocol analysis (PP, n = 177). Two years after delivery, normalization of maternal BMI and number of infants with BMI < 19 kg/m2 were not significantly different in the interventional group in ITT and in the control group. Although not significantly different in ITT, normalization of maternal BMI was more frequent in AD (n = 149: 12.9% vs 3.8%, p = 0.04) and 2-year-old infant BMIs were less likely to be >19 kg/m2 in the intervention group in AD (n = 204: 0% vs 6.8%, p = 0.014) and PP (n = 176: 0% vs 6.4%, p = 0.03).


An education and nutritional counseling program for overweight women, starting after 3 months of gestation, did not significantly change post-natal excessive weight gain of infants or prevent overweight in mothers and children 2 years after delivery.

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The authors thank Christelle Auger, Valérie Jolaine, Christelle Turuban, and France Binet (Paris Descartes Clinical Research Unit) for their help in managing the protocol and collecting the data. Fiona Ecarnot (EA3920, University Hospital Besancon, France) participated in the writing of the paper.

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Author notes

  1. These authors contributed equally: Sophie Parat, Véronique Nègre.


  1. AP-HP, Department of Medecine and Neonatal Reanimation, Hôpital Cochin-Port Royal, Paris, France

    • Sophie Parat
  2. RePPOP-Franche Comte Network for Pediatric Obesity, Obesity Specialized Center CHU Nice, Paris, France

    • Véronique Nègre
  3. URC/CIC Paris Descartes Necker Cochin, Paris, France

    • Amandine Baptiste
    • , Jean-Marc Tréluyer
    •  & Caroline Elie
  4. AP-HP, CRNH-IdF, CINFO, COMUE Sorbonne-Paris-Cité, Department of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, Bondy, France

    • Paul Valensi
    •  & Emmanuel Cosson
  5. Department of Pediatric Endocrinology, CHRU, Besançon, France

    • Anne-Marie Bertrand
  6. Childhood Hospital and RePPOP Midi Pyrenees Network for Pediatric Obesity, Toulouse, France

    • Christine Chollet
  7. AP-HP, Nutrition Obesity Unit, Necker Hospital, Paris, France

    • Myriam Dabbas
  8. AP-HP, Department of Diabetology, HEGP, Paris, France

    • Jean-Jacques Altman
  9. AP-HP, Department of Neonatology, Paris Descartes University, Hôpital Necker, Paris, France

    • Alexandre Lapillonne
  10. Department of Pediatric Endocrinology, Childhood Hospital and RePPOP Midi Pyrenees Network for Pediatric Obesity, Toulouse, France

    • Maithé Tauber
  11. Department of Endocrinology, Paule Viguier Hospital, Toulouse, France

    • Françoise Lorenzini
  12. Université Paris 13, Inserm (U1153), Inra (U1125), Centre d’Epidémiologie et Statistiques Paris Cité, Cnam, COMUE Sorbonne-Paris-Cité, F-93017, Bobigny, France

    • Emmanuel Cosson


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The authors declare that they have no conflict of interest.

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Correspondence to Sophie Parat.

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