Fig. 2: The expression of five types of SSTRs and SST family genes in excitatory and inhibitory neurons in the VISp and ALM. | Experimental & Molecular Medicine

Fig. 2: The expression of five types of SSTRs and SST family genes in excitatory and inhibitory neurons in the VISp and ALM.

From: The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders

Fig. 2

a Mean gene expression (RPKM: reads per kilobase of transcript per million mapped reads) of SSTR1–5, CST, and SST in excitatory neurons (left column) and inhibitory neurons (right column) in the VISp. The data are from mouse single-cell RNA sequencing data from the Allen Brain Atlas (total 15,413 cells; version 2018)28. The bars represent the mean ± SEM. Genetic markers of the cortical layers were selected based on previous literature99. Rasgrf2 Ras protein-specific guanine nucleotide releasing factor 2, Calb1 calbindin1, Rorb RAR-related orphan receptor B, Scnn1α sodium channel epithelial 1 subunit alpha, Rbp4 retinol-binding protein 4, Trib2 Tribbles pseudokinase 2, Ctgf connective tissue growth factor, Pvalb parvalbumin, Sst somatostatin, Vip vasoactive intestinal peptide, GAD glutamate decarboxylase. b Same as a, but for the ALM (total 10,068 cells). Cux2 was used as a genetic marker of layer 2/3 excitatory neurons instead of Calb1. Cux2 Cut-like homeobox 2.

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