Fig. 2: Differentiation of exhausted T cells. | Experimental & Molecular Medicine

Fig. 2: Differentiation of exhausted T cells.

From: Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion

Fig. 2

T cell activation generates both short-lived effector cells with terminally differentiated features and memory precursors. If the infection is cleared without delay (acute infection), the short-lived effector cells die, and the memory precursors give rise to long-lived memory T cells. However, if the infection persists without resolution (chronic infection), the memory precursors generate PD1+CXCR5+TCF1+ progenitors of exhausted T cells that self-renew to maintain the pool of mature exhausted T cells (PD1+TCF1-). It appears that these progenitors of exhausted T cells phenotypically resemble memory progenitors during acute infection, but they functionally differ in the generation of daughter cells.

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