Table 1 List of anticancer drugs according to their effect on intracellular ROS, and types of cancer where are used.

From: ROS in cancer therapy: the bright side of the moon

NameMechanism to increase ROSCancers treatedRef.
SulfasalazineXCT inhibitorPancreatic and small-cell lung cancer69,70
NOV-002GSSG mimeticHER2-negative breast cancer71
Imatinib (PDGFR inhibitor)Loss of mitochondrial membrane potentialMelanoma88
Erlotinib (EGFR inhibitor)Loss of mitochondrial membrane potentialNon-small-cell lung cancer89
Vemurafenib (BRAF inhibitor)Depolarization of mitochondrial membraneMelanoma90
Rituximab (anti-CD20)Inhibition of Bcl-2 via mitochondrial ROSB-cell lymphoma91
ProcarbazineOxidized, generates ROSHodgkin’s lymphomas, brain cancer96
DoxorubicinFenton’s reaction and electron leakageKaposi’s sarc, breast and bladder cancer, ALL97
Arsenic trioxideElectron leakageMyeloma, lung cancer and leukemia100,101
5-fluorouracilP53-dependent ROSColon and rectal cancer102,103
2-methoxyestradiolLoss of mitochondrial membrane potentialNeuroblastoma104
N-(4-hydroxyphenyl retinamideMitochondrial damageLung cancer105
Platinum drugsROS-dependent DNA damageBreast cancer (in ccombination with PARP inhibitors)106,107
GamitrinibMitochondrial collapseProstate cancer110
ARQ 501 and STA-4783Leakage of electron transportPancreatic adenocarcinoma and solid tumors111
BortezomibROS due to ER stressHead and neck squamous cell carcinoma112
CelecoxibROS after ER stressProstate cancer113
SanguinarineElectron leakage and induction of NOXsGlioma119
RapamycinROS from ER stressRAS-driven tumors120