Table 1 DNA virus evasion of STING-dependent innate immunity

From: STING signaling and host defense against microbial infection

VirusViral genesMechanismsReferences
HSV-1ICP27Interacts with TBK1 and STING and prevent IRF3 activation.29
g134.5Disrupts STING trafficking from ER to Golgi and inhibit IRF3 activation.36
VP22Interact with cGAS and Inhibit the enzymatic activity of cGAS.31
VP24Blocks phosphorylation and dimerization of IRF3 but not NF-kB.30
UL24Prevents IL-6 production by NF-kB.35
UL46Colocalizes with STING and inhibit interferon stimulating gene transcription.32
UL41Decreases cGAS accumulation and prevent cGAMP production.33
UL37Deamidates cGAS, similarly resulting in impaired CDN production.34
UL36Block promoter activation IFNb and NF-kB induced by cGAS and STING depending on its deubiquitinase activity.37
KSHVvIRF1Prevents STING from interacting with TBK1.40
ORF52Binds to both DNA agonist and cGAS and impede CDN production.41
LANADirectly binds to cGAS and inhibit STING signaling.42
CMVM152Binds to STING and inhibit STING signaling.45
HBVPolInterferes with the K63-linked polyubiquitination of STING via its reverse transcriptase (RT) domain.50
AdE1AInhibits the cGAS/STING pathway by directly binding to STING.28
HPVE7Inhibits the cGAS/STING pathway by directly binding to STING.28