Table 4 Bile acid profiles in the liver of mice (nmol/mg protein)

From: Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling

Bile acid (nmol/mg)UntreatedGMVCMp valuea (GM vs. untreated)p valuea (VCM vs. untreated)
ωMCA6.53 ± 13.5410.88 ± 12.300.45 ± 0.400.5010.031
αMCA3.90 ± 6.8510.80 ± 11.321.87 ± 0.920.1440.043
βMCA19.42 ± 26.35131.80 ± 151.3442.01 ± 21.490.0440.119
HCA0.09 ± 0.200.22 ± 0.350.04 ± 0.030.3550.160
CA8.04 ± 18.8730.30 ± 30.671.21 ± 0.420.0880.018
muroCA0.64 ± 0.700.21 ± 0.170.04 ± 0.040.1090.019
CDCA0.16 ± 0.190.64 ± 0.740.19 ± 0.080.0780.110
7DHCA7.47 ± 20.5228.03 ± 47.270.12 ± 0.050.2530.117
12DHCA0.39 ± 0.361.32 ± 1.450.22 ± 0.160.0820.051
3DHCA0.03 ± 0.040.07 ± 0.100.01 ± 0.020.3380.114
Total unconjugated primary BAs46.68 ± 86.67214.26 ± 202.7356.16 ± 22.350.0390.035
TωMCA134.20 ± 133.85681.24 ± 1609.9030.64 ± 35.880.3240.272
TαMCA201.87 ± 379.71207.65 ± 561.5819.96 ± 35.210.9800.361
TβMCA1950.61 ± 2393.9611916.86 ± 9826.945212.38 ± 3520.190.0100.091
THCA4.47 ± 8.1115.14 ± 15.581.29 ± 1.340.0910.025
TCA422.81 ± 460.481643.28 ± 1950.49602.53 ± 445.130.0880.163
GCDCA0.09 ± 0.100.09 ± 0.100.04 ± 0.010.9300.202
GCA0.46 ± 0.650.85 ± 0.840.08 ± 0.060.2980.022
TCDCA51.44 ± 53.44156.11 ± 189.7059.05 ± 28.440.1320.174
Total conjugated primary BAs2765.95 ± 3172.8814621.24 ± 12816.425925.97 ± 3934.010.0170.088
6ketoLCA0.03 ± 0.030.06 ± 0.050.02 ± 0.020.2470.040
7ketoLCA0.01 ± 0.010.06 ± 0.080.01 ± 0.010.0800.071
UDCA0.60 ± 0.583.51 ± 3.500.68 ± 0.340.0260.039
HDCA0.30 ± 0.310.15 ± 0.200.06 ± 0.030.2670.210
DCA0.19 ± 0.190.13 ± 0.290.02 ± 0.030.6380.283
Total unconjugated secondary/tertiary BAs1.13 ± 1.043.91 ± 4.070.78 ± 0.410.0650.088
TLCA4.58 ± 4.031.13 ± 0.830.62 ± 0.140.0320.112
TUDCA74.77 ± 83.98343.98 ± 304.56110.74 ± 72.670.0220.054
THDCA28.98 ± 42.550.34 ± 0.570.27 ± 0.680.0770.825
TDCA81.59 ± 87.850.81 ± 0.580.06 ± 0.070.0200.003
Total conjugated secondary/tertiary BAs189.91 ± 203.07346.26 ± 305.59111.69 ± 73.280.2280.053
  1. The data are the means ± SDs
  2. aOne-way ANOVA was used to compare differences between the GM vs. untreated groups and between the VCM vs. untreated groups