Table 3 Bile acid profiles in the serum of mice (nmol/L)

From: Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling

Bile acid (nmol/mg)UntreatedGMVCMp valuea (GM vs. untreated)p valuea (VCM vs. untreated)
7DHCA16.49 ± 5.9549.26 ± 71.740.76 ± 1.090.1910.076
12DHCA2.10 ± 1.231.99 ± 3.020.89 ± 1.320.9220.357
3DHCA1.65 ± 0.485.12 ± 6.230.40 ± 0.560.1150.051
ωMCA99.09 ± 74.6519.22 ± 18.572.66 ± 5.990.0070.029
α MCA32.61 ± 15.6713.99 ± 20.096.57 ± 10.650.0430.366
βMCA103.13 ± 101.17109.10 ± 120.1868.23 ± 103.940.9110.468
HCA4.03 ± 3.830.76 ± 0.640.24 ± 0.370.0220.064
CA38.44 ± 40.7957.36 ± 225.4146.20 ± 72.060.3800.475
CDCA2.79 ± 4.634.84 ± 11.203.99 ± 5.710.6180.849
muroCA4.20 ± 2.980.14 ± 0.170.11 ± 0.180.0010.752
Total unconjugated primary BAs304.53 ± 151.43261.77 ± 474.62130.05 ± 198.350.9660.331
TωMCA9.69 ± 8.501.89 ± 1.022586.99 ± 4881.970.0150.132
TαMCA2.76 ± 1.101.42 ± 0.9013.97 ± 16.070.0120.033
TβMCA40.20 ± 31.752812.86 ± 890.148187.01 ± 1435.990.0030.007
THCA0.11 ± 0.086.96 ± 20.403.73 ± 6.350.3290.674
TCA4.08 ± 1.75724.17 ± 2164.71725.16 ± 1270.960.3330.999
GCDCA0.03 ± 0.020.06 ± 0.120.05 ± 0.020.5670.818
GCA0.05 ± 0.030.38 ± 1.100.10 ± 0.150.3790.481
TCDCA3.90 ± 2.2551.22 ± 121.6049.13 ± 63.790.2600.966
Total conjugated primary BAs60.82 ± 32.453598.96 ± 1593.3511566.14 ± 2200.340.0330.031
6ketoLCA2.76 ± 2.060.35 ± 0.140.03 ± 0.040.0030.000
7ketoLCA1.35 ± 0.900.74 ± 2.520.27 ± 0.380.6670.125
UDCA12.98 ± 8.667.98 ± 13.853.94 ± 6.230.3720.459
HDCA16.78 ± 15.480.20 ± 0.190.25 ± 0.340.0050.727
DCA62.74 ± 38.620.25 ± 0.2830.47±116.530.0000.019
total unconjugated secondary/tertiary BAs96.61 ± 51.1510.52 ± 16.5054.72 ± 46.000.0000.019
TLCA0.39 ± 0.410.05 ± 0.150.22 ± 0.440.0320.301
TUDCA1.27 ± 0.540.88 ± 0.59137.22 ± 250.430.1640.122
THDCA0.90 ± 0.620.07 ± 0.200.85 ± 2.190.0020.301
TDCA6.12 ± 4.070.14 ± 0.290.43 ± 1.050.0010.449
total conjugated secondary/tertiary BAs7.90 ± 5.071.14 ± 0.61138.72 ± 252.730.0010.140
  1. The data are the means ± SDs
  2. aOne-way ANOVA was used to compare differences between the GM vs. untreated groups and between the VCM vs. untreated groups