Table 1 Characteristics of the patients

From: Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling

VariablePatients without cholestasisPatients with cholestasisp valuea
Patients (n)26200.25
Short bowel syndrome (n)690.59
Male (n)16110.69
Age (months)5 (3.3–6)5 (3.1–7)0.87
Gestational age (weeks)37 (31.5–38)36 (30–39)0.58
Gestational weight (g)2900 (1486–3162)2650 (2030–3025)0.08
Plasma alkaline phosphatase, ALP (U/L)240.5 (201.5–286.5)275 (173–311.6)<0.01
Plasma alanine aminotransferase, ALT (U/L)45 (31.5–89)56 (33.6–97)<0.01
Plasma aspartate aminotransferase, AST (U/L)59 (47.9–98.7)67 (56.5–114.5)<0.01
Plasma total bilirubin (μmol/L)9.7 (9.2–18.5)13.5 (9.5–34.2)0.01
Plasma conjugated bilirubin (μmol/L)2.3 (0.2–5.2)10.5 (9.3–22.5)0.03
Serum IL-6 (pg/mL)4.2 (4.6–7.8)7.7 (4.3–41.5)<0.01
Serum TNF-α (pg/mL)6.9 (0.7–14.7)8.6 (7.3–15.4)<0.01
  1. The data are the medians (ranges)
  2. aComparison between patients with and without cholestasis using Fisher’s exact test or the Mann–Whitney U test