Fig. 2: Intestinal failure (IF) patients with cholestasis exhibit disrupted FXR signaling. | Experimental & Molecular Medicine

Fig. 2: Intestinal failure (IF) patients with cholestasis exhibit disrupted FXR signaling.

From: Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling

Fig. 2

a The expression of FXR and its target genes in the ileum was significantly lower in patients with cholestasis (n = 12) than in subjects without cholestasis (n = 8). b Serum FGF19 decreased in patients with cholestasis (n = 26) compared to those without cholestasis (n = 20). c Alterations in the expression of FXR and downstream genes in liver tissues (without cholestasis, n = 16, with cholestasis, n = 12). d Representative images of FXR and CYP7A1 immunohistochemical staining in liver tissues of patients. Scale bar = 25 µm; *p < 0.05, **p < 0.01

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