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Y-chromosome evidence confirmed the Kerei-Abakh origin of Aksay Kazakhs

Abstract

Aksay Kazakhs are the easternmost branch of Kazakhs, residing in Jiuquan city, the forefront of the ancient Silk Road. However, the genetic diversity of Aksay Kazakhs and its relationships with other Kazakhs still lack attention. To clarify this issue, we analyzed the non-recombining portion of the Y-chromosome from 93 Aksay Kazakhs samples, using a high-resolution analysis of 106 biallelic markers and 17 STRs. The lowest haplogroup diversity (0.38) was observed in Aksay Kazakhs among all studied Kazakh populations. The social and cultural traditions of the Kazakhs shaped their current pattern of genetic variation. Aksay Kazakhs tended to migrate with clans and had limited paternal admixture with neighboring populations. Aksay Kazakhs had the highest frequency (80%) of haplogroup C2b1a3a1-F3796 (previous C3*-Star Cluster) among the investigated Eurasian steppe populations, which was now seen as the genetic marker of Kerei clan. Furthermore, NETWORK analysis indicated that Aksay Kazakhs originated from sub-clan Kerei-Abakh in Kazakhstan with DYS448 = 23. TMRCA estimates of three recent descent clusters detected in C2*-M217 (xM48) network, one of which incorporate nearly all of the C2b1a3a1-F3796 Aksay Kazakhs samples, gave the age range of 976-1405 YA for DC1, 1059-1314 YA for DC2, and 1139-1317 YA for DC3, respectively; this is coherent with the 7th to the 11th centuries Altaic-speaking pastoral nomadic population expansion.

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References

  1. 1.

    Yao YG, Kong QP, Wang CY, Zhu CL, Zhang YP. Different matrilineal contributions to genetic structure of ethnic groups in the silk road region in China. Mol Biol Evol. 2004;21:2265–80.

    CAS  Article  Google Scholar 

  2. 2.

    Geng SM. On Kazak spoken and written language. N W Ethno-Natl Stud. 2006;2:56–63.

    Google Scholar 

  3. 3.

    Dulik MC, Osipova LP, Schurr TG. Y-chromosome variation in Altaian Kazakhs reveals a common paternal gene pool for Kazakhs and the influence of Mongolian expansions. PLos One. 2011;6:e17548.

    CAS  Article  Google Scholar 

  4. 4.

    Gokcumen O, Dulik MC, Pai AA, Zhadanov SI, Rubinstein S, Osipova LP, et al. Genetic variation in the enigmatic Altaian Kazakhs of South-Central Russia: insights into Turkic population history. Am J Phys Anthropol. 2008;136:278–93.

    Article  Google Scholar 

  5. 5.

    Xie, GX, Wang, XP. History of the Kazakhs in the Gansu province of China. Lanzhou: Gansu Culture Press (2009).

  6. 6.

    Abilev S, Malyarchuk B, Derenko M, Wozniak M, Grzybowski T, Zakharov I. The Y-chromosome C3* Star-Cluster Attributed to Genghis Khan’s Descendants is Present at High Frequency in the Kerey Clan from Kazakhstan. Hum Biol. 2012;84:79–89.

    Article  Google Scholar 

  7. 7.

    Tarlykov PV, Zholdybayeva EV, R Akilzhanova A, M Nurkina Z, M Sabitov Z, Rakhypbekov TK, et al. Mitochondrial and Y-chromosomal profile of the Kazakh population from East Kazakhstan. Croat Med J. 2013;54:17–24.

    Article  Google Scholar 

  8. 8.

    Zerjal T, Wells RS, Yuldasheva N, Ruzibakiev R, Tyler-Smith C. A genetic landscape reshaped by recent events: Y-chromosomal insights into central Asia. Am J Hum Genet. 2002;71:466–82.

    CAS  Article  Google Scholar 

  9. 9.

    Zhabagin M, Sarkytbayeva A, Tazhigulova I, Yerezhepov D, Li S, Akilzhanov R, et al. Development of the Kazakhstan Y-chromosome haplotype reference database: analysis of 27 Y-STR in Kazakh population. Int J Leg Med. 2019;133:1029–32.

    Article  Google Scholar 

  10. 10.

    Zhabagin M, Balanovska E, Sabitov Z, Kuznetsova M, Agdzhoyan A, Balaganskaya O. The connection of the genetic, cultural and geographic landscapes of transoxiana. Sci Rep. 2017;7:3085.

    Article  Google Scholar 

  11. 11.

    Wang CC, Wang LX, Shrestha R, Zhang M, Huang XY, Hu K, et al. Genetic structure of qiangic populations residing in the western Sichuan corridor. PLoS ONE. 2014;9:e103772.

    Article  Google Scholar 

  12. 12.

    Wen SQ, Xu D, Yao HB, Li H. Present Y Chromosomes Refute the Roma/Gypsy Origin of the Xuejiawan People in Northwest China. In: XU Dan, LI Hui (eds) Languages and Genes in Northwestern China and Adjacent Regions. Singapore: Springer, 107–20 (2017).

  13. 13.

    Hu K, Yan S, Liu K, Ning C, Wei LH, Li SL, et al. The dichotomy structure of Y chromosome Haplogroup N. arXiv:1504.06463 https://arxiv.org/abs/1504.06463v1 (2015).

  14. 14.

    Zhivotovsky LA, Underhill PA, Cinnioğlu C, Kayser M, Morar B, Kivisild T, et al. The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time. Am J Hum Genet. 2004;74:50–61.

  15. 15.

    Zhang D, Cao G, Xie M, Cui X, Xiao L, Tian C, et al. Y Chromosomal STR haplotypes in Chinese Uyghur, Kazakh and Hui ethnic groups and genetic features of DYS448 null allele and DYS19 duplicated allele. Int J Legal Med. https://doi.org/10.1007/s00414-019-02049-6 (2019).

  16. 16.

    Wei LH, Yan S, Lu Y, Wen SQ, Huang YZ, Wang LX, et al. Whole-sequence analysis indicates that the Y chromosome C2*-Star Cluster traces back to ordinary Mongols, rather than Genghis Khan. Eur J Hum Genet. 2018;26:230–7.

    CAS  Article  Google Scholar 

  17. 17.

    Malyarchuk B, Derenko M, Denisova G, Wozniak M, Grzybowski T, Dambueva I, et al. Phylogeography of the Y-chromosome haplogroup C in northern Eurasia. Ann Hum Genet. 2010;74:539–46.

    CAS  Article  Google Scholar 

  18. 18.

    Huang YZ, Wei LH, Yan S, Wen SQ, Wang CC, Yang YJ, et al. Whole sequence analysis indicates a recent southern origin of Mongolian Y-chromosome C2c1a1a1-M407. Mol Genet Genomics. 2018;293:657–63.

    CAS  Article  Google Scholar 

  19. 19.

    Wei LH, Huang YZ, Yan S, Wen SQ, Wang LX, Du PX, et al. Phylogeny of Y-chromosome haplogroup C3b-F1756, an important paternal lineage in Altaic-speaking populations. J Hum Genet. 2017;62:915–8.

    CAS  Article  Google Scholar 

  20. 20.

    Balaresque P, Poulet N, Cussat-Blanc S, Gerard P, Quintana-Murci L, Heyer E, et al. Y-chromosome descent clusters and male differential reproductive success: young lineage expansions dominate Asian pastoral nomadic populations. Eur J Hum Genet. 2015;23:1413–22.

    CAS  Article  Google Scholar 

  21. 21.

    Rogers JD. Inner Asian states and empires: theories and synthesis. J Archaeol Res. 2012;20:205–56.

    Article  Google Scholar 

  22. 22.

    He H. Annals of the autonomous prefecture of Aksai Kazaks. Lanzhou: Gansu People’s Publishing House (1993).

  23. 23.

    Zhang C. Simple study of the national characteristics Kazak Islamic religion. J Changchun Univ Sci Technol (Soc Sci Ed). 2010;23:39–42.

    Google Scholar 

  24. 24.

    Zerjal T, Xue Y, Bertorelle G, Wells RS, Bao W, Zhu S, et al. The genetic legacy of the Mongols. Am J Hum Genet. 2003;72:717–21.

    CAS  Article  Google Scholar 

Download references

Acknowledgements

We are grateful for the trust of the sample donors. This work was supported by National Social Science Foundation of China (19VJX074), Scientific and Technology Committee of Shanghai Municipality (18490750300), National Natural Science Foundation of China (91731303, 81671874, 31760309, 31771325, 91631105, and 31801040), Innovation Team Project of Fundamental Research Funds for the Central Universities (31920190030), and 111 Project (B13016).

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Correspondence to Shao-Qing Wen, Xiao-Dong Xie or Hui Li.

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Wen, SQ., Sun, C., Song, DL. et al. Y-chromosome evidence confirmed the Kerei-Abakh origin of Aksay Kazakhs. J Hum Genet 65, 797–803 (2020). https://doi.org/10.1038/s10038-020-0759-1

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