Clinical Investigation | Published:


Serum levels of C1q/tumor necrosis factor-related protein-1 in children with Kawasaki disease

Pediatric Research volume 83, pages 9991003 (2018) | Download Citation



To investigate the serum C1q/tumor necrosis factor-related protein-1 (CTRP1) levels in children with acute Kawasaki disease (KD), as well as the relationship between CTRP1 levels and laboratory variables.


Eighty-seven children with KD and 38 healthy controls (HCs) were included in this study. General characteristics were obtained from all subjects. Serum CTRP1 levels in all subjects and serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels in KD patients were measured using enzyme-linked immunosorbent assay.


Compared with the HC group, serum CTRP1 levels were significantly elevated in the KD group. Significantly higher serum TNF-α, IL-1β, IL-6, and CTRP1 levels were observed in patients with KD with coronary artery lesions (KD-CALs) than in patients with KD without CALs (KD-NCALs). Serum CTRP1 levels were positively correlated with white blood cell counts (WBC), percentage of neutrophils (N%), thrombin time (TT), procalcitonin (Pct), TNF-α, IL-1β, and IL-6 levels. Meanwhile, CTRP1 levels were negatively correlated with the percentage of leukomonocytes (L%) in KD patients. Furthermore, serum CTRP1 levels were positively correlated with the time point of intravenous immunoglobulin (IVIG), WBC, N%, TNF-α, IL-1β, and IL-6 levels in the KD-CAL group.


CTRP1 may participate in the process of vasculitis and blood coagulation during the acute phase of KD.

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We acknowledge Hu Dou in Children’s Hospital of Chongqing Medical University for his help in collecting consents from patients and receiving the samples and we thank all children enrolled in the study for their kindness.

Ethical approval: The study protocol was approved by the Ethics Committee of Children’s Hospital of Chongqing Medicine University, and written informed consent forms were obtained from the parents or other guardians of all subjects.

Author information


  1. Key Laboratory of Pediatrics in Chongqing, Chongqing, China

    • Siqi Feng
    •  & Ya Su
  2. Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China

    • Li Luo
    •  & Fengchuan Jing
  3. Department of Cardiovascular Medicine, Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China

    • Qijian Yi


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The authors declare no conflict of interest.

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Correspondence to Qijian Yi.

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