Figure 1

From: Human hepatocyte transplantation for liver disease: current status and future perspectives

Figure 1

Fate of allogeneic hepatocytes after transplantation. After transplantation, allogeneic hepatocyte engrafts into the recipient’s liver. In case of selective advantage over the host cells or in the presence of proliferative stimuli, transplanted hepatocytes repopulate the liver. Immune rejection is the main cause of cell loss and graft failure. Potential ways to improve engraftment and inhibit allogeneic hepatocyte loss are listed. Intensity of blue in the background highlights the level of clinical benefits associated to the different conditions. ALF, acute liver failure.