Abstract
Objective: To study the clinical value of cerebral glucose metabolism measure by 18F-fluorodeoxyglucose 18F-FDG PET in preterm, term newborn infants and neonatal hypoxic-ischemic encephalopathy (HIE).
Methods: To measure the cerebral glucose metabolism by 18F-FDG PET imaging in newborn infants. Sixty infants were included in the study. The data was collected by PET instrument after administration of 0.1mCi /kg 18F-FDG, and standardized uptake values (SUV) were calculated to estimate the cerebral glucose metabolism.
Results: The cerebral glucose metabolism was found to have a trend to be increased, and the structure of brain 18F-FDG PET imaging to be clear with the increase of gestational age, especially when the gestational age was older than 37wk. The brain 18F-FDG PET imaging in different gestational age showed that the uptake of 18F-FDG was relatively higher in thalamus, cerebellum, sensorimotor cortex and basal ganglia, where as relatively lower in cerebral cortex. The uptakes of 18F-FDG in ≥37wk group were found to be significantly higher than those in ≤32wk group (p< 0.01). The cerebral glucose metabolism was significantly changed in neonatal HIE. The cerebral uptake of 18F-FDG was either unbalanced bilaterally or relatively low in all sites especially in subcortical alba, thalamus, basal ganglia in HIE patients. Moreover, The uptakes of 18F-FDG in severe HIE patients were found to be significantly lower than those in mild and medium HIE patients(p< 0.05).
Conclusions: Cerebral glucose metabolism measured by 18F-FDG PET might be a useful tool for estimating the brain development and injury in newborn infants, and its clinical values need further investigating.
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Shi, Y., Jin, R. & Li, H. Cerebral Glucose Metabolism Measured by Positron Emission Tomography in Preterm, Term Newborn Infants and Neonatal Hypoxic-Ischemic Encephalopathy. Pediatr Res 70 (Suppl 5), 728 (2011). https://doi.org/10.1038/pr.2011.953
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DOI: https://doi.org/10.1038/pr.2011.953