Abstract
Background: Therapeutic hypothermia reduces morbidity and mortality in infants with neonatal encephalopathy. Clinical trials are investigating lower temperatures as tailoring cooling with precision may provide benefit.
Aims: To assess systemic effects of whole body cooling to 35oC, 33.5oC and 30oC in piglet model of perinatal asphyxia.
Methods: Twenty eight newborn anaesthetised piglets, underwent standardized HI insult then randomised (all groups n=7), with intervention from 2-26h to i) normothermia (N); ii) cooling to rectal temperature 35°C; iii) 33.5°C, or iv) 30°C.
Results: During cooling, HR was lower at 30°C vs N (p=< 0.001); MABP did not differ between groups. Inotrope and volume replacement were higher at 30°C vs other groups (p=< 0.05). Blood pH and glucose were deranged at 12h (p=< 0.05) vs N and 35oC, respectively. Blood lactate was deranged at 24h (p=0.05). BE was deranged at 12 and 24h at 30°C vs all other groups (p=< 0.05)(Fig 1 A-D).
Conclusions: Cooling to 30°C led to prolonged adverse systemic effects. In-advertant overcooling should be avoided in infants undergoing therapeutic hypothermia.
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Kerenyi, A., Kelen, D., Faulkner, S. et al. Systemic Effects of Whole-Body Cooling to 35, 33 and 30°c in a Piglet Model of Perinatal Asphxyia. Pediatr Res 70 (Suppl 5), 661 (2011). https://doi.org/10.1038/pr.2011.886
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DOI: https://doi.org/10.1038/pr.2011.886