Abstract
Background: The adequate management of FiO2 adjustment depends on the feedback evaluation of heart rate (HR) and saturation of oxygen (SO2) values.
Objective: To evaluate HR and SO2 responses in 15s and 30s delays following FiO2 changes.
Methods: Thirty one of EPI £ 28 weeks were resuscitated and stabilized in a special bed equipped with two cameras enabling the evaluation of all interventions, monitoring HR and SO2 values and the actual FiO2, PIP and PEEP levels provided by a T piece device. The TRAL sequence analysis software makes it possible to concurrently evaluate different images recorded at the same time. FiO2 was started at 0.30 and further adjusted according to the guided SO2. The multiple linear regression tested the relationship between FiO2 as an independent variable and dependent variables such as SO2 and HR in real time, with a 15s and 30s delay, and in the opposite dependence. The Massimo pulse oximeter set up at a 2 sec interval was used. The Spearman Rank Correlation evaluated the probability of all relations.
Results: Although a significant negative correlation between FiO2 levels and HR and SO2 values was confirmed (R= - .302, t= .000; R= -.359, t= .001), no significant correlations were found comparing FiO2 changes and those of HR and SO2 following 15s and 30s intervals
(R= -.031, t= .541; R=-.018, t= .726).
Conclusion: FiO2 adjustment does not dominate oxygenation of EPI during the first 5 minutes of life. Establishing an adequate functional residual capacity may be the preferable skill.
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Lamberska, T., Vankova, J. & Plavka, R. Should be Oxygenation of Extremely Premature Infants (EPI) Guided by FIO2 Adjustment during the First Five Minutes of Life?. Pediatr Res 70 (Suppl 5), 252 (2011). https://doi.org/10.1038/pr.2011.477
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DOI: https://doi.org/10.1038/pr.2011.477