Abstract
Background and object: According to Institute of Medicine, serum 25-hydroxyvitamin D (S-25-OHD) < 30 nmol/L indicates high risk for rickets. Vitamin D status, as assessed by S-25-OHD, is often poor in normal healthy mothers and their infants in Northern latitudes. Routine supplementation (200 IU/d) of all newborns has recently commenced in Ireland The object of this study was to assess S-25OHD status in maternal and term umbilical cord samples and at follow-up in those neonates with S-25OHD < 30 nmol/L.
Methods: S-25-OHD levels were evaluated from maternal (n=44) and umbilical cord samples (n=56) from term normal pregnancies in a consecutive sample of cases. Parents of infants with S-25-OHD < 30nmol/l (n=15) were invited to attend for repeat sampling.
Results: 115 samples included 44 maternal and 56 cord samples and 15 follow-up neonatal samples for infants with cord samples < 30nmol/l. The mean of cord blood 25OHD levels were significantly decreased compared with maternal levels. However the neonatal follow-up samples were significantly increased compared to maternal and cord levels in each subgroup (Table1).
Conclusions: We demonstrated a high prevalence of poor vitamin D status at the time birth in mothers and their infants that was rectified by low dose (200 IU/d) supplementation.
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Diya, B., Onwumeme, C., Uduma, O. et al. Poor Vitamin D Status in Healthy Mothers and Infants: Resolution in Neonates on 200 IU Daily. Pediatr Res 70 (Suppl 5), 789 (2011). https://doi.org/10.1038/pr.2011.1014
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DOI: https://doi.org/10.1038/pr.2011.1014