Abstract
Background and aims: Early treatment of cryptorchidism may be necessary to preserve fertility and international guidelines recommend that congenital cryptorchidism be treated with orchiopexy before one year of age. Acquired cryptorchidism should be treated at presentation. The adherence to guidelines during recent years is not known, and the aim of this study is to present data on age at cryptorchidism diagnosis and orchiopexy in recent Danish birth cohorts.
Methods: A population of 502,815 Danish boys born alive from January 1, 1995 to October 21, 2009 was identified using The Danish Civil Registration System. Five birth cohorts were defined, 1995-1997, 1998- 2000, 2001-2003, 2004-2006 and 2007-2009. The boys were followed in the Danish National Registry of Patients for a diagnosis of cryptorchidism and for an orchiopexy procedure. Data was analyzed using the Kaplan-Meier estimator and Cox regression models.
Results: During follow-up, 9,479 boys were diagnosed with cryptorchidism and 5,076 of these underwent orchiopexy. The mean age (years) at diagnosis among boys followed at least 5.8 years was: 1995-1997 cohort, 3.30 (95 % confidence interval: 3.23; 3.37); 1998-2000 cohort, 3.08 (3.01; 3.15); 2001-2003 cohort, 2.79 (2.73; 2.86). The corresponding mean age (years) at orchiopexy was: 1995-1997 cohort, 3.75 (3.65; 3.85); 1998-2000 cohort, 3.54 (3.45; 3.63); 2001-2003 cohort, 3.18 (3.10; 3.26). Restriction of the analyses to 427,650 term (gestational age ≥ 37 weeks) singletons did not substantially change the results.
Conclusions: In the more recent birth cohorts of 1995 to 2006 we found a shift towards younger age at cryptorchidism diagnosis and orchiopexy.
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Jensen, M., Olsen, L., Thulstrup, A. et al. 486 Age at Cryptorchidism Diagnosis and Orchiopexy: A Population-Based Study of 502,815 Danish Boys Born From 1995 to 2009. Pediatr Res 68 (Suppl 1), 249 (2010). https://doi.org/10.1203/00006450-201011001-00486
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DOI: https://doi.org/10.1203/00006450-201011001-00486