411 Postnatal Early Catch-Up Growth and Insulin Sensitivity in Small for Gestational Age Infants.

Abstract

Objective: To explore the relationship of postnatal catch-up growth and insulin sensitivity.

Methods: Fasting glucose, insulin and HOMA value in 44 small for gestational age (SGA) infants and 74 appropriate for gestational age (AGA) infants at age 3 month were studied by a prospective study, and the relations with catch up growth were analyzed in 44 SGA infants.

Results: SGA infants had significantly higher fasting insulin concentration and HOMA value than did AGA infants. Adjustment for gestation, there was a negative association between velocity of catch-up growth and insulin concentration and HOMA value in SGA infants (P < 0. 05). 12 non-catch-up growth in weight and length infants had significantly higher fasting insulin concentration and HOMA value than did they on the third day after birth in SGA group respectively [ insulin : (21. 92 ±14. 25) mU /L vs (11. 08 ±9. 59) mU /L P < 0. 05 ; HOMA : (4. 15 ±2. 96) vs (1. 86 ±1. 71), P < 0. 05 ].

Conclusions: Catch-up growth is closely related with insulin sensitivity in early postnatal life, and poor growth might result in worse insulin sensitivity in SGA infant s during that time.

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Wang, X., Cui, Y. & Han, T. 411 Postnatal Early Catch-Up Growth and Insulin Sensitivity in Small for Gestational Age Infants.. Pediatr Res 68, 211 (2010). https://doi.org/10.1203/00006450-201011001-00411

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