Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

188 Preterm-Born Infants Produce Less Melatonin Than Term-Born Infants at 9 and 12 Months of Age: A Randomized Controlled Trial

Abstract

Background: Melatonin production is known to be delayed in preterm-born infants up to 6 months of age. We aimed to test the profile of melatonin production in these infants at 9-12 months of age.

Methods: Twenty three term-born and 23 preterm-born infants (gestational age: 29-34 weeks) were randomly assigned. We tested nocturnal urinary melatonin excretion, within a repeated measures design, both at 9 and 12 months of age. Nocturnal urine was extracted from diapers and urinary melatonin derivate (6-sulphatoxymelatonin) excretion was analyzed by ELISA assay.

Results: Preterm-born infants had significantly lower urinary melatonin excretion both at 9 and 12 months of age as compared to term-born infants. At 9 months: 8502 ± 6215 vs 12735 ±10284 ng, and at 12 months: 8623 ± 5095 vs 14985 ± 10890 ng respectively, [F (1,42)=4.276], (p < 0.05).

Conclusion: At 9 and 12 months of age, the delayed maturation of melatonin production is still persistent in preterm-born infants as compared to term-born mates. The impact of persistent decreased melatonin production in preterm-born infants up to 12 months of age on their psychomotor development is to be elucidated.

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Goldstein, S., Makhoul, I. 188 Preterm-Born Infants Produce Less Melatonin Than Term-Born Infants at 9 and 12 Months of Age: A Randomized Controlled Trial. Pediatr Res 68, 98 (2010). https://doi.org/10.1203/00006450-201011001-00188

Download citation

Search

Quick links