Abstract
Introduction: mechanical ventilation is a necessarytherapy in critical pathologies with respiratory failure, producing acute pulmonary injury.
Objectives: To identify an acute pulmonary injuryby bronchioalveolar lavage cytology and determinecausal relations with the Fraction of inspired Oxygen(FiO2), the pressure of the airways, positive endexpiratorypressure (PEEP), oxygen saturation andexposure time.
Methods: Longitudinal, prospective clinicalinvestigation from January to July 2007, whichincluded 51 patients that received mechanicalventilation. 153 bronchioalveolar lavage citologieswere obtained and processed.
Results: Several alterations in citologies wereobserved at 12, 72 and 144 hours after mechanicalventilation was started, which shows a simpleand meaningful statistic association with fractionof given oxygen at 12 and 74 hours, PEEP at 12hours, Pressure in air ways and and oxygen.
Discussion: It becomes evident that alterationsproduced by mechanical ventilation are connectedwith FiO2, oxygen saturation, absence or low PEEPand elevated airway pressure.
Conclusion: Alterations in citologies of thebronchioalveolar epithelium present themselves inthe presence of FiO2 and low PEEP.
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Urbina-Medina, H. 1336 Acute Pulmonary Lesion Caused by Mechanical Ventialtion. Pediatr Res 68 (Suppl 1), 661 (2010). https://doi.org/10.1203/00006450-201011001-01336
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DOI: https://doi.org/10.1203/00006450-201011001-01336