Abstract
Objective: To compare the effectiveness of the ibuprofen and acetaminophen in children with fever.
Subjects and Methods: Design: An experimental study (controlled, randomized, double blind) was performed, with design of clinical test. Subjects: Febrile children from 4 months to 10 years of age, receiving medical care in a emergency service. Interventions: At random each boy was assigned to receive a single dose of acetaminophen (15mg/kg), ibuprofen (10mg/kg) or placebo (5 ml/kg).
Results: 197 patients were included in the study, 64 were administered with acetaminophen, 67 ibuprofen and 66 placebo. The temperature was measured at the moment the patient‘s arrival; then it was measured 10, 20 and 30 minutes and 1, 2, 3, 4, 5 and 6 hours later. It was managed to decrease the temperature below 38°C in 55 patients receiving acetaminophen, in 56 patients receiving ibuprofen and in 32 patients receiving placebo. The comparison between each of them was made to value the effectiveness. Between acetaminofen and ibuprofeno was obtained x2 = 0.14, p = 0.70; between acetaminofen and placebo x2 = 20.43; p = 0.000006; between ibuprofeno and placebo X2=18.16, p = 0.00004.
Conclusions: The antipyretic effectiveness of acetaminophen and ibuprofen is significantly greater than placebo. Between acetaminophen and ibuprofen, we did not observe statistically significant differences.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
De La O Vizcarra, M., Medrano, R., Mújica, D. et al. Study Comparative of the Effect Against the Fever of the Acetaminophen vs Ibuprofen in Children of 6 Months to 6 Years Old: P089. Pediatr Res 60, 639 (2006). https://doi.org/10.1203/00006450-200611000-00044
Issue Date:
DOI: https://doi.org/10.1203/00006450-200611000-00044