Abstract
OBJECTIVE the aim of this study was to examine cord blood adiponectin, high molecular weight form of adiponectin (HMW) and leptin concentrations in full-term neonates, and their correlations with anthropometric parameters at birth.
DESIGN Venous cord blood samples were obtained from 135 full-term healthy newborns (57 males and 78 females, gestational age 37.0–41.6 weeks, birth weight 2,261–4,164 g, birth length 43–55 cm, birth head circumference 29–36.5 cm).
MEASUREMENTS the adiponectin and leptin concentrations were determined by enzyme-linked immunosorbent (ELISA) assays using commercially available kits. The HMW concentration was determined by ELISA originally developed by Nakano Y.
RESULTS the adiponectin, HMW and leptin concentrations in cord blood were 30.4 ± 10.4 μg/ml, 29.7 +/- 11.6 μg/ml, and 5.8 +/- 4.2 ng/ml, respectively. The percentage of HMW in the adiponectin concentrations was 99 +/- 30%. The concentrations of leptin in female infants were significantly higher than those in male infants (p < 0.05), but there was no significant gender differences in adiponectin and HMW concentrations among newborns. Plasma adiponectin, HMW and leptin levels had significantly positive relationships with birth weight, birth length, birth head circumference and birth weight/birth length ratio. Plasma leptin concentrations were also positively correlated with placental weight (r = 0.342, p < 0.001). Plasma adiponectin and HMW concentrations were correlated with leptin concentrations (r = 0.286, p < 0.01, r = 0.304, p < 0.001, respectively).
CONCLUSIONS These results indicate that the adiponectin concentration in newborn infants mainly exists in a HMW form, and the concentrations of plasma adiponectin, HMW and leptin may reflect fetal growth.
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Itahashi, K., Inoue, M., Nakano, Y. et al. 179 Cord Blood Adiponectin, High Molecular Weight Form of Adiponectin and Leptin in Full- Term Neonates Are Positively Correlated with Anthropometric Para. Pediatr Res 58, 385 (2005). https://doi.org/10.1203/00006450-200508000-00208
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DOI: https://doi.org/10.1203/00006450-200508000-00208