Abstract 163
Aim Intra-muscular supplementation of vitamin A in large doses has been shown to decrease the incidence of chronic lung disease (CLD) in premature babies. We aimed to investigate whether oral supplementation with vitamin A would reduce the incidence of CLD in a group of extremely low birth weight babies.
Method Babies with birth weight <1000g were randomised at birth to receive oral vitamin A supplementation (5000units daily) or placebo for 28 days. The primary outcome was oxygen dependency at 28 days of age.
Results 147 babies were randomised, 73 received vitamin A (median birth weight (IQR) 806 (697-880) g) and 74 received placebo (median birth weight(IQR) 785 (669-880) g). (Table).
Conclusion Oral supplementation with vitamin A in extremely low birth weight babies did not significantly alter the incidence of chronic lung disease.
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Wardle, S., Hughes, A., Chen, S. et al. RANDOMISED CONTROLLED TRIAL OF ORAL VITAMIN A SUPPLEMENTATION TO PREVENT CHRONIC LUNG DISEASE. Pediatr Res 45, 914 (1999). https://doi.org/10.1203/00006450-199906000-00181
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DOI: https://doi.org/10.1203/00006450-199906000-00181