Abstract 1834

Surfactant (Survanta; S), partial liquid (PLVSM) and high frequency ventilation (HFV) each improve gas exchange in lung-injured animals and humans. We evaluated physiologic responses in 32 piglets with saline lavage-induced lung injury (PaO2<60 torr at FiO2 1.0) treated for 20 hours with conventional ventilation (CV; Babylog)+S+PLV (28.5±5.7 mL/kg; n=8); HFV (SensorMedics 3100)+S (n=8); HFV+S+loPLV (10 mL/kg; n=8) or HFV+S+PLV (27.5±6.8 mL/kg; n=8). We hypothesized 1) HFV+S+PLV improves gas exchange compared to CV+S+PLV or HFV+S, and 2) HFV+S+loPLV is similar to other PLV modalities. Animals received S (100 mg/kg); PLV animals received intratracheal perflubron (LiquiVent®) after S. Evaporative losses were replaced hourly by assessing meniscus; in the HFV+S+loPLV group, we added 3 mL/kg/hr. We adjusted ventilators as in clinical use, and measured physiologic variables (heart rate, blood gases, a/A, OI, blood pressure, airway pressure) at baseline; after injury, S and perflubron treatments; and hourly. Data analysis used 2-factor ANOVA and Newman-Keuls tests. All techniques provided similar physiologic stability. HFV required higher Paw. Means shown. (Table)

Table 1 No caption available
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Conclusions: Gas exchange and cardiovascular stability were similar in all groups. HFV+S+loPLV was not different from other PLV groups. Perflubron provided by/ equity in (MCM, PM) Alliance Pharmaceutical Corp.; Partial funding provided by grants from the Children's Health Care Foundation and Ross Labs Inc; Survanta provided by Ross Labs Inc.