In an effort to improve circulation in children post respiratory arrest(RA), we examined the effects of dobutamine (D) on the hemodynamic function of piglets.

Methods: Two groups (N=5) of 4-7 week old piglets were anesthetized, received a tracheostomy, insertion of an endotracheal tube, and were mechanically ventilated to a normal PaCO2 and PaO2 in room air. Baseline measurements of CV parameters were recorded after a one hour recovery. The endotracheal tubes were clamped for 8 minutes after which the pigs were resuscitated. Following resuscitation, the animals were randomized toGroup 1 (no intervention) or Group 2(dobutamine infusion at 10 mcg/kg/min). CV parameters were measured at 15, 75, and 135 minutes post RA. CV calculations were performed using standard formulas. Statistical analysis was performed using multivariate analysis controlling for baseline values.

Results: Central venous, pulmonary artery, and pulmonary wedge pressures, heart rate and pulmonary vascular resistance were not statistically different. Other results are shown in the following Table (P value <.05* is significant, CI=cardiac index(L/min/m2), MAP=mean arterial pressure (mmHg), SVRI=systemic vascular resistance (dyne-sec/cm5/m2).

Table 1 No caption available.
Full size table

Conclusion: Dobutamine prevented a rise in SVRI which allowed for maintenance of near normal CV function following respiratory arrest. Dobutamine may be useful in improving cardiovascular function following respiratory arrest.