Abstract 212

AIM was to investigate the effects of late vs. early cord clamping on systemic circulation and regional cerebral blood flow velocity(CBFV) in prematures <1500g.

SUBJECTS: 19 neonates were studied 4 hours after caesarean section. In 11 neonates (birth weight: 1240 ±290g; gestational age: 30.0 ±2 wks) the umbilical cords were clamped after 30 seconds and the infants were placed 30 cm below placenta level (Late), and in 8 (1231±350g; 28.6 ±2 wks) the umbilical cords were clamped immediately (Early). Volume expansion (serum or plasma) were given to keep the mean blood pressure (MBP) >30 mmHg.

METHODS: MBP (mmHg, Dinamap), left ventricular output (LVO, ml/kg/min), mean cerebral blood flow velocity (CBFV) in the Arteria carotis interna (ACI, m/s; Doppler-ultrasound), hemoglobin (Hb, g/dl), and hematocrit (Hct, %) were measured. Systemic and cerebral hemoglobin transport(HbT), and systemic vascular resistance (SVR; mmHg/kg/min-1) were estimated. Statistic: *unpaared t-test.Table

Table 1

CONCLUSION: Late cord clamping improves MBP, systemic vascular resistance, hemoglobin, systemic and cerebral hemoglobin transport in prematures <1500g. The early cord clamped group required more volume expansion in the first 24 h (Early: 7/8, 14 ±7ml/kg; Late: 2/11, 5 ±4ml/kg; p<0.03).