45 newborns (450-4620 gms) who needed endotracheal intubation were included in a prospective study to test the role of a disposable pediatric entotracheal CO2 detector (Pedi-Cap) in verifying endotracheal tube position. Of the 45 babies 24 (53.3%) were intubated in the delivery room and 21 (46.7%) in the NICU. The Pedi-Cap color indicator correlated with the clinical evaluation and X-ray finding of proper intubation in 30 out of 33 patients (sensitivity 91%, specificity 100%, positive predictive value 100%, and negative predictive value 80%). There were three false negative results in patients with severe cardiorespiratory depression. The Pedi-Cap color indicator correlated with the clinical evaluation for the Et-tube being in the esophagus in 12 out of 12 patients (sensitivity, specificity, positive predictive value and negative predictive value were all 100%). The time required to determine the tube position by clinical evaluation was 0-90 seconds (Mean 39.7 sec. SD±15.3). The time required with the disposable Et-CO2 detector was 4-12 seconds (Mean=8.1 sec. SD±2.9). (p<0.001). The use of disposable pediatric entotracheal CO2 detector significantly reduces the time spent in verifying the endotracheal tube position (trachea vs. esophagus) in newborns including premature babies with body weight <1000 grams. This is of particular benefit to the babies who are erroneously intubated in the esophagus because using the device allows much faster detection of this problem and much earlier reintubation.