Malignancies related to infection with the human immunodeficiency virus(HIV) are a part of the disease spectrum. We report six children (ages 2 to 9 years) with perinatally acquired HIV infection diagnosed with malignancies over a 6 year period at our center which followed an average of 250 HIV infected children over this period at any given time.Table

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Our experience demonstrates the increasing spectrum of malignancies to which children with HIV infection are susceptible.Although toxicity may be severe, antineoplastic therapy should be considered as durable remission is possible.