Aim: To test comparatively various NO-synthase (NOS) inhibiting or NOS substrates L-arg analogs on the neonatal renal vasculature .Subjects, interventions: Isolated kidneys from 7 day old (N=20) and adult rabbits (N=20) were perfused in vitro in control conditions, or in the presence of 10-4 M L-NAME, L-NMMA, L-NAME + L-arg or L-NAME + BAEE. Perfusion pressure measured at constant flow was considered to reflect RVR.
Results: RVR in ml/min/mmHg, (means ± SEM,*:p<0.05 compared to controls)Table
Conclusion: L-arg analogues exert specific effects on the neonatal rabbit renal vasculature. L-NAME is a more potent NOS inhibitor than L-NMMA, and BAEE allows a better reversion of the NOS inhibition in the newborn animal Evidence on the biologic roles of NO in the neonatal kidney may depend on the NOS inhibitor/substrate which are used in the experiments.
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Simeoni, U., Zhu, B., Messer, J. et al. Effect of L-Arginine (L-arg) analogues on renal vascular resistance (RVR) in the neonatal rabbit kidney. Pediatr Res 42, 411 (1997). https://doi.org/10.1203/00006450-199709000-00176
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DOI: https://doi.org/10.1203/00006450-199709000-00176
