Three courses of IDM, 500 mg/m2 at three week intervals, were given to 126 children, and three courses of HDM, 2-6 g/m2, in 6 high risk children, as part of sanctuary treatment following induction therapy of a Norwegian treatment protocol during the period 1975-1980. No prophylactic irradiation was used.
A follow-up study of 93 (70%) survivors of this protocol and 5 of an other 21 cases of ALL in childhood diagnosed during the same 6-year-period, was performed.
A questionnaire of 10 pages with medical and psychosocial questions was used, with a family control in each case.
Forms were received in a total of 94 (96%) of the 98 surviving patients with leukemia, and on corresponding controls.
There was no significant difference between the 2 groups with respect to physical and mental health.
The research work was done in all departments of Pediatrics in Norway.
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Moe, P., Glomstein, A., Madsen, B. et al. QUALITY OF LIFE IN PATIENTS TREATED WITH A NATIONAL ALL PROTOCOL 15-10 YEARS EARLIER: IDM/HDM AND LATE EFFECTS? 123. Pediatr Res 41, 769 (1997). https://doi.org/10.1203/00006450-199705000-00142