We have prospectively evaluated anthropometrics and blood pressure(BP) in a cohort of term IGDM (39 Large for gestation (LGA) & 42 Appropriate for gestation(AGA) and Controls(C)(44 LGA & 39 AGA) at birth and 26 mos. to evaluate the effects of neonatal macrosomia on adiposity and BP. We hypothesized that LGA IGDM would continue to have increased central adiposity at 2 yrs. of age which would be related to their BP. Results: B.wt and 26 mo data are shown: Table The body mass index (BMI) of LGA IGDM, and AGA and LGA controls were significantly greater than AGA IGDM. LGA IGDM, however, had significantly greater abdominal skinfolds(SF) (p<.03) at 2 years than all other study groups. In addition, for IGDM, infant BMI correlated with 2 yr. BMI (r=.36,p<.001) and infant mean BP correlated with 2 yr BP (r=.36,p<.01). Control infants BMI correlated with child BMI(r=.23,p,.03) but C infant BP did not correlate with child BP. At 2 yrs child weight also correlated with BP for IGDM (r=.26,p<.04) but not controls. We conclude that the altered intrauterine environment which contributes to macrosomia in the IGDM has lasting effects on adiposity distribution and BP, and that increased BP is related to central adiposity.

Table 1
Full size table