AIMS: A pilot study in preterm infants to determine the effect of inhaled nitric oxide therapy (INO) on urinary malondialdehyde (MDA),a product of lipid peroxidation and a marker of oxidant/antioxidant activity.
SUBJECTS:Preterm infants < 32 weeks receiving INO therapy(part of randomised controlled study).
METHODS: Estimation of urinary malondialdehyde (MDA) by high performance liquid chromatography. Urine samples were collected before and during INO therapy and at comparable times in control infants.
RESULTS: 11 infants studied - 6 received INO and 5 did not. There were no significant differences between urinary MDA in the INO treatment and control groups prior to treatment and at 6 hours and 24 hours post treatment. However, urinary MDA was lower in the INO treated group at 48 hours(p=0.014 Mann Whitney U test).
CONCLUSION: Inhaled nitric oxide reduces lipid peroxidation in preterm infants with respiratory distress.
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Richard W.Cooke (sponsored by A.M.Weindling).
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Drury, J., Nycyk, J., Subhedar, N. et al. Lipid Peroxidation During Nitric Oxide Therapy in Preterm Infants 72. Pediatr Res 40, 527 (1996). https://doi.org/10.1203/00006450-199609000-00095
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DOI: https://doi.org/10.1203/00006450-199609000-00095
