HIGH-FREQUENCY JET VENTILATION (HFJV) & CONVENTIONAL VENTILATION(CV): GAS EXCHANGE AND AIRWAY PRESSURES. † 2000

We examined gas exchange and and airway pressures in 142 preemies entered in a randomized study of CV & HFJV at 8 centers. Infants were eligible if they were 700-1500g and required mechanical ventilation with ≥30% O₂>2h after surfactant. The prescribed high-volume strategy defined as PEEP≥7cmH₂O or a ≥1cmH₂O PEEP increase from baseline (HI) was used in 34/69 HFJV patients; in 35 standard HFJV strategy of low peak and mean pressure was used (LO). Data were analyzed by ANOVA for repeat measures and are expressed as mean±SEM. PIP and delta p were lower with HFJV than CV(p<0.001). The a/A ratio was higher with HF-HI than CV and HF-LO(p<0.05). HF-LO resulted in more hyperventilation when compared to HF-HI and CV (p<0.05). Better oxygenation and less hypocarbia favor the use of HF-HI over HF-LO. Figure

Figure 1