Mucormycosis refers to disease caused by fungi belonging to the orderMucorales. These saprophytic fungi are ubiquitous in the environment. Disease primarily occurs in debilitated patients with diabetes, neoplasm or other immunocompromise. Although mucormycosis has been reported in neonates, the disease is still considered rare in this population. Three neonates with documented mucormycosis were diagnosed over a period of three years (1993-1995) at Strong Memorial Hospital. Strong Memorial Hospital is a tertiary care center with busy neonatal and pediatric intensive care units. All infants were younger than one month of age at onset of disease. Two were premature infants at 25 and 30 weeks estimated gestational age. The remaining patient was a full term infant with severe tricuspid atresia. Diagnosis was made on one patient by premortem biopsy culture and tissue stain, one by postmortem culture and autopsy tissue slides, and one by tissue staining at autopsy alone. The two cases with positive cultures grew Absidia species. The clinical presentations varied widely and included a sepsis picture, a gangrenous cellulitis, and a non-specific pulmonary infiltrate. The patient with gangrenous cellulitis received treatment with Amphotericin b and extensive debridement of the necrotic tissue. The diagnosis was not made premortem in the other two cases and they did not receive antifungal treatment. All three patients died. Two patients died of complications attributable to mucormycosis. The cause of death in the patient with tricuspid atresia was felt to be related to poor response to the surgical shunting procedures rather than fungal infection. The documentation of three cases of neonatal mucormycosis in a three year period should serve as an indicator of a growing “at risk” group of immunocompromised patients. Clinicians involved in the care of sick neonates, especially those with prematurity, should be alert to the increasing importance of this and other opportunistic pathogens and consider appropriate diagnostic evaluations.