Abstract
Failure of growth is frequent in patients (P) with end stage renal disease (ESRD) and after renal TX. We studied serum IGF-1 and IGF-bindinq protein-3 (IGFBP-3) levels (RIA) in 18 ESRD P on dialysis 8.0-29.5 years old (x:18.7), and in 19 TX P 4.7-21.8 years old (x:12.9). ESRD P had lower mean IGF-1 levels (x±sd:0.66+0.25 U/ml) than TX P (1.77±0.89 U/ml, p < 0.001). In contrast, mean IGFBP-3 was higher in ESRD P (8.0±2.43 mg/L) than in TX P (5.78±1.21 mg/L, p < 0.001). Mean IGFBP-3 levels in both groups of P (6.86±2.19 mg/L) was higher than in controls (n=38) (4.53±1.47 mg/L, p < 0.001). When P were divided in Tanner I (n= ESRD:6 & TX:11) and Tanner IV-V stages (n= ESPD:11 & TX:8) IGF-1 and IGFBP-3 levels were:
IGF-1 levels correlated with height SDS for chronological age in ESRD (r:0.63) and in TX P (r:0.67). In TX P, there was a significant correlation between IGFBP-3 and IGF-1 levels (r:0.53) and between IGFBP-3 and Tanner stage (r: 0.56). We conclude that increased levels of IGF3P-3 may be implicated in IGF inhibition. The physiologic elevation of IGF-1 levels during puberty was observed in TX P but not in ESRD P.
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Pasoualini, T., Fainstein-Day, P., Gutman, R. et al. SERUM IGF-l AND IGF-BINDING PROTEIN-3 LEVELS BEFORE AND AFTER RENAL TRANSPLANTATION (TX). Pediatr Res 38, 624 (1995). https://doi.org/10.1203/00006450-199510000-00042
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DOI: https://doi.org/10.1203/00006450-199510000-00042