Abstract
TMN, secondary to transplacental passage of antibodies directed to acetylcholine receptors, has been reported in 10 to 12% of infants born to myasthenic mothers. Symptoms may appear at 72 hrs. or up to 7 days due to passage of maternal medication. It is a different entity from Congenital Myasthenia inasmuch as the latter has no maternal history of the disease. The present paper reports data from 6 infants born to myasthenic mothers between 3/88 an 3/93. We retrospectively considered perinatal data, symptoms attributable to TMN (hipotonia, asbsent/decreased reflexes, suction, facial expression, apnea/hypoventilation, and IMV requirements) use of antibiotics, response to medication and length of hospital stay. All mothers had received treatment (Prostigmin (R)) during pregnancy. Two infants had no symptoms out of the rest (2 brothers) all were hypotonic; 3/4 had apnea or weak suck; 3/4 required IMV, and all 3 received aminoglycosides after being placed on the ventilador; 2/4 had decreased reflexes and /or facial expression. All 4 received specific medication (Prostigmin (R)). Mean length of stay was 40 days. These data show that TMN may be more frequent than reported and entiails increased neonatal morbidity. Although controversial, different maternal therapy (IVIG, steroids and/or plasmapheresis) might decreased the incidence of TNM.
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Azcarate, A., Araujo, G., Lazzari, M. et al. TRANSIENT MYASTHENIA NEONATORUM (TMN). Pediatr Res 36, 827 (1994). https://doi.org/10.1203/00006450-199412000-00048
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DOI: https://doi.org/10.1203/00006450-199412000-00048