Abstract
MAbs against enzymes of the brush border provide a new approach to evaluate intestinal lesions in severe PD. The 10 patients with PD in whom a small bowel biopsy was performed during 1992 were evaluated by means of MAbs for lactese (L), sucrase (S), maltsse (M) and aminopeptidase (A); results were compared with those of light mi croscopy, histochemistry lor lactase, disacchandase activities (Dalqvist) and clinical history. Diagnosis was DP and severe malnutrition (MN) in 4 cases, congenital sucrose intolerance (CSI) 1, cow's milk protein intolerance (CMI) 2, celiac disease (CD) 1, sIgA deficiency 1 and cryptosporidias is (Crypt) 1. The latter was the only child with a positive ethiologic study.
MAP ofr sucrase detected more enzyme than Dalqvist, which may be interpreted as tht MAP binds non-functional molecules. In patient with CSI, MAP for sucase detedted less enzyme than Dalqvist, which is in agreement with the production of a defective molecule.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Araya, M., Espinoza, J., Alliende, F. et al. EVALUATION OF SMALL INTESTINE FUNCTION IN INFANTS WITH PERSISTENT DIARRHEA (PD) USING MONOCLONAL ANTIBODIES (MAbs). Pediatr Res 36, 827 (1994). https://doi.org/10.1203/00006450-199412000-00047
Issue Date:
DOI: https://doi.org/10.1203/00006450-199412000-00047