Abstract
The prevalence and treatment of glucose intolerance were evaluated in 18 cystic fibrosis patients.
With this objective, 10 females and 8 males with ages varying from 8 to 19 years were submited to oral glucose tolerance test (OGTT) associated with the following determinations: glycated haemoglobin, C-peptide, anti Langerhans cells antibodies and fasting glucose level.
The diagnosis was made in 8/18 patients (41%) only by the OGTT. All other laboratory tests were normal. In 3 patients with malnutrition and delayed puberty, we used insulin. Form these 3 patients, 2 of them had a good recovery both on nutritional and pubertal development.
In conclusion we found a high prevalence of glucose intolerance in cystic fibrosis patients. The OGTT was the only procedure to identify these patients. We speculate that the use of insulin could be an important useful therapy in these patients.
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Liberatore, R., Zullo, M., Nakaie, C. et al. STUDIES OF PREVALENCE OF GLUCOSE INTOLERANCE IN CYSTIC FIBROSIS PATIENTS: EXPERIENCE WITH THE USE OF INSULIN. Pediatr Res 36, 825 (1994). https://doi.org/10.1203/00006450-199412000-00037
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DOI: https://doi.org/10.1203/00006450-199412000-00037