Abstract
There is a lack of data on the level of I in P and CSF during neonatal cardiovascular collapse. Moreover, disturbances in glucose (G) homeostasis influences brain metabolism profoundly Therefore, we have studied 10 newborn piglets (Group 1) during the course of PTX measuring I by a RIA method and G concentrations In P and CSF. Stages ol the disease were baseline; critical phase 65.0 ± 3.4 min after the beginning of the induction of PTX (MABP: 16.8 ± 05 mmHg; HR: 54.7 ± 1.4 min−1. pH: 6.89 ± 0.04, pO: 25.0 ± 2.0 mmHg), when animals were given 10 ml x b.w.kg−1 4.2 %v:v NaHCO3 /V infusion and recovery (samples were taken 0, 120 and 240 min after the beginning of PTX and in critical phase). Data were compared to results taken from sham operated animals without PTX (Group 2, n=9, sampling at 0, 60, 120 and 240 min); all values are means ± SEM), *p < 0.05 compared to values in Group 2
Conclusion: A significant hypoglycemia develops with a concomitant elevation of insulin levels in P and CSF in piglets with experimental PTX.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Temesvàrl, P., Ábrahám, C., Kovács, J. et al. PLASMA (P) AND CEREBROSPINAL FLUID (CSF) INSULIN (I) CONCENTRATION IS ELEVATED IN PIGLETS WITH EXPERIMENTAL NEONATAL PNEUMOTHORAX (PTX). Pediatr Res 35, 262 (1994). https://doi.org/10.1203/00006450-199402000-00049
Issue Date:
DOI: https://doi.org/10.1203/00006450-199402000-00049