Abstract
There is a lack of data on the level of I in P and CSF during neonatal cardiovascular collapse. Moreover, disturbances in glucose (G) homeostasis influences brain metabolism profoundly. Therefore, we have studied 10 newborn piglets (Group 1) during the course of PTX moasuring I by a RIA method and G concentrations in P and CSF, Stages of the disease were baseline; critical phase 65.0 ± 3.4 min after the beginning of the Induction of PTX (MABP:16.8 ± 05 mmHg; HR; 64.7 ± 1 4 min−1, pH: 6.89 ± 0.04, pO: 26.0 ± 2.0 mmHg). when animals were given 10 ml × b.w.kg−1 4.2 % v:v NaHCO1 /v Infusion and recovery (samples wore taken 0, 120 and 240 mm after the beginning of PTX and In critical phase). Data were compared to results taken from sham operated animals without PTX (Group 2. n=9. sampling at 0. 60, 120 and 240 min); all values are moans ± SEM). *p < 0.05 compared to values in Group 2.
Conclusion: A significant hypoglycemia dovolops with a concomitant elevation of insulin levels in P and CSF in plglets with oxporlmontal PTX.
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Temesvárl, P., Ábrahám, C., Kovács, J. et al. PLASMA (P) AND CEREBROSPINAL FLUID (CSF) INSULIN (I) CONCENTRATION IS ELEVATED IN PIGLETS WITH EXPERIMENTAL NEONATAL PNEUMOTHORAX (PTX). Pediatr Res 35, 261 (1994). https://doi.org/10.1203/00006450-199402000-00043
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DOI: https://doi.org/10.1203/00006450-199402000-00043