Abstract
Within the framo of a study on the influence of intra-uterine hypoxia on the maturation of the adrenal medulla, the ontogeny of different neurochemical marker o in the adrenal modulla of the pig was studied. Obtained data are the result of measurements on the extract of the adrenals of all piglete from one litter. Gestational age was determined according to the crown-rump length of the piglets (full term being about day 114 of gestation). Adrenal from pig fetuses with 16 different gestational ages between 43 and 100 daya were investigated. The amount of adrenaline (A) increases with gestational age. The noradrenaline (NA) content as well as the dopamine-β-hydraxylane (DβH) content augment steeply at about day 60, are maximal at about day 75 and decline slightly towards term. The ratio A/NA rises with gestational age. The chromogranin A (CgA) content in maximal at about day 65 and also decreases slightly towarde term (Table).
Conclusion: In the pig adrenal medulla A, NA and CgA synthesis early in gestation, before adrenal innervation is completely (around birth). This suggests an important role of the adrenal in the regulation of hemodynamics prior to and shortly after birth.
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Laroche, S., Van Reempts, P., Pinxteren, J. et al. ONTOGEMY OF NEUROCHEMICAL MARKERS IN THE ADRENAL MEDULLA OF THE PIG. Pediatr Res 35, 261 (1994). https://doi.org/10.1203/00006450-199402000-00039
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DOI: https://doi.org/10.1203/00006450-199402000-00039