Abstract
A group of sixty-five at-risk neonates was enrolled in a prospective follow-up study in order to assess the relationship between the degree of Cerebral Visual Impairment, established using the Acuity Card Procedure, and the extent of neurological sequelae. Furthermore, MR- and CT-scans were performed in all infants with severe neurological sequelae to study whether characteristic lesions occurred in the central visual pathway.
Eleven out of twelve infants with an acuity on or below the 10th centile at 18 months developed cerebral palsy: the underlying condition was extensive cystic leukomalacia in all. However, an acuity above the 10th centile was no guarantuee for a normal development, as ten out of 52 infants developed cerebral palsy; six had a large peri/intraventriculat haemorrhage, four had cystic leukomalacia.
MR- and CT-scans showed, that periventricular high signal intensity in the occipital area was found to be a non-specific finding with regards to visual function. Very extensive periventricular white matter loss and involvement of the striate/parastriate cortex was found in the most severely visually impaired infants.
p.Eken was supported by the ‘praeventiefonds’ (grant no. 28-1406)
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Eken, P., De Vries, L., Der Graaf, Y. et al. 60 HAEMORRHAGIC-ISCHAEMIC LESIONS OF THE NEONATAL BRAIN: CORRELATION BETWEEN CEREBRAL VISUAL IMPAIRMENT, NEURODEVELOPMENTAL OUTCOME AND MRI IN INFANCY. Pediatr Res 36, 12 (1994). https://doi.org/10.1203/00006450-199407000-00060
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DOI: https://doi.org/10.1203/00006450-199407000-00060