Abstract
OBJECTIVE: LBW neonates have a decreased ability to clear intravenous lipids. The use of 201 rather than 101 long chain triglyceride (LCT) enulsion has been shown to result in lower plasma lipid concentrationI. The aim of this study was to examine the effect of concentration of a mixed medium chain triglyceride (HCT)/LCT enulsion.
DESIGN & METHOD: Infants requiring parenteral nutrition were randomised to receive 101 or 201 Lipofundin HCT/LCT (Braun). This was connenced at 0.5 g/kg/day and increased stepwise to 3 g/kg. Triglyceride and cholesterol levels were aeasured twice weekly. Growth parameters, non-esterified fatty acids (NEFA) and ketone bodies (KB) were neasured weekly.
RESULTS: 55 infants were studied, 26 of whom received 10% Lipofundin. The mean (SD) birthweight was 1274 (660 g) gestation was 28.9 (3.5) wks and duration of parenteral nutrition was 21 (11.4) days. There were no significant differences between the groups. Mean cholesterol in mnol/l at weekly intervals are shown below:
Infants receiving 10% Lipofundin had significantly higher plasna cholesterol. Serun triglycerides tended to be higher in the 10% group and increase with tine but this was not significant. There was no difference in NEFA, KB or growth parameters.
CONCLUSION: The preterm neonate tolerates 20% MCT·LCT infusion better than 10% infusion.
Ref 1. - D Haunont. J Padiatr 1959; 115: 787-93.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cairns, P., Wilson, D., Mcclure, G. et al. 43 LIPID TOLERANCE IN MEOMARES GIVE 20% VS 10% MIXED MCT/LCI LIPID EMULSION – RANDONISED TRIAL. Pediatr Res 36, 10 (1994). https://doi.org/10.1203/00006450-199407000-00043
Issue Date:
DOI: https://doi.org/10.1203/00006450-199407000-00043