Abstract
During an ongoing study on CBF in the first 72 hours of life we tried to see if a critical low CBF value is associated with brain damage assessed either by autopsy or by Bayley's test at 18 months, CBF was measured in fifty-six premature infants (GA: 26-33 weeks) with the i.v.Xe-133 method. Infants with minor brain damage (Bayley MDI 75-90) showed higher CBF values (mean CBF 15.0; SD 3.3) than infants with seven, brain damage (Bayley MDI <75or cystic leucomalacia in autopsy n=5) (mean CBF 9.9; SD 2.2; t test p<0.001). Children with a normal outcome at 18 months (Bayley MDI >90) showed CBF' values ranging from 6,6 to 19.7 ml/100g/miu. (mean CBF: 12.8 SD 3.4) Girls with normal outcome tend to have lower CBF values than boys (t test p=0.046).
Conclusion: Infants with CBF as low as 6.6 ml/100g/min can have a normal Hayley's test at 18 months.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Müller, A., Morales, C., Bucher, HU. et al. IS LOW CEREBRAL BLOOD FLOW (CBF) IN PREMATURE INFANTS COMPATIBLE WITH NORMAL NEURODEVELOPMENTAL OUTCOME?. Pediatr Res 35, 281 (1994). https://doi.org/10.1203/00006450-199402000-00158
Issue Date:
DOI: https://doi.org/10.1203/00006450-199402000-00158