Abstract
Previously we demonstrated that indomethacin (IND) reduced basal RBF, but had no effect on ChBF and did not modify the hyperoxic response. We speculated that inhibition of cycloxygenase was the mode of action, but could not exclude other pharmacological properties of IND. To establish if this effect during normoxia was due in cyclooxygenase inhibition, the effect of IB, a specific cyclooxygenase blocker, was investigated in newborn piglets, age ≤7 days old. We also wanted to verify possible role of the prostanoids as mediators of hyperoxic vasoconstriciton. Ocular blood flow was examined before (RA1) and after (RA2) either saline (controls; S, n = 7), or ibuproten infusion (30mg/kg) (IB, n = 9), and after 90 min of hyperoxia (O2). Radiolabeled microspheres were used to measure blood flow. Results: (ml/min/100g tissue±SEM):
RBF was significantly reduced by IB whereas ChBF was not. Further, hyperoxia significantly decreased RBF and ChBF in both groups. Thus, our results suggest that prostanoids play a role in maintaining basal retinal vascular tone. However, the response in hypemxia is mediated through mechanisms other than the byproducts of arachidonic acid metabolism.
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Stiris, T., Suguihara, C., Bancalari, E. et al. THE EFFECT OF IBUPROFEN (IB) ON RETINAL (RBF) AND CHOROIDAL (ChBF) BLOOD FLOW DURING NORMOXIA AND HYPEROXIA IN NEWBORN PIGLETS. Pediatr Res 35, 269 (1994). https://doi.org/10.1203/00006450-199402000-00089
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DOI: https://doi.org/10.1203/00006450-199402000-00089