Abstract
ABSTRACT: In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2−/NO3−), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF). Anti-TNF MAb cotreatment was shown to blunt hypoglycemia and hyper-lacticemia and was associated with decreased mortality of septic animals. Moreover, anti-TNF MAb significantly reduced not only plasma TNF but also plasma NO2−/NO3− levels. Dcxamcthasone had a similar effects, and when anti-TNF MAb was used in combination with dexamethasone, the suppression of nitric oxide production and the protective efficacy were more remarkable compared with therapy with either anti-TNF MAb or dexamethasone alone. Our present data suggested that the protective efficacy of anti-TNF MAb may correlate with the suppression of nitric oxide production and also with a modulation in metabolic abnormalities in the septic newborn rats.
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Shi, Y., Li, HQ., Shen, CK. et al. Association between Protective Efficacy of Antibodies to Tumor Necrosis Factor and Suppression of Nitric Oxide Production in Neonatal Rats with Fatal Infection. Pediatr Res 34, 345–348 (1993). https://doi.org/10.1203/00006450-199309000-00021
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DOI: https://doi.org/10.1203/00006450-199309000-00021