Abstract
ABSTRACT: The influence of fetal glucose and amino acid supply on the regulation of fetal plasma IGF-I levels was investigated in fetuses from starved ewes. Paired maternal and fetal blood samples were taken during an initial 2-d control period, after 48 h of maternal starvation, during a 24-h fetal infusion of glucose (n = 6) or an amino acid mixture (Synthamin 17, n = 5) with continued starvation, and after 48 h of maternal refeeding. After 48 h of starvation, maternal and fetal plasma IGF-I, insulin, and blood glucose fell significantly in both groups compared with control values (IGF-I for glucose group: maternal, −18.53 ± 6.60; fetal, −5.23 ± 1.81 nmol/L; amino acid group: maternal, −18.2 ± 6.97, fetal, −5.12 ± 1.61 nmol/L; both p < 0.05). Fetal glucose but not mixed amino acid infusion raised fetal plasma IGF-I, insulin, and blood glucose to near control values (glucose group fetal IGF-I, −1.77 ± 1.98; amino acid group, −5.93 ± 2.22 nmol/L; both p < 0.05). Maternal plasma IGF-I remained depressed during glucose infusion (−16.33 ± 8.32 nmol/L), but continued to fall in the amino acid group (−21.41 ± 8.20 nmol/L, p < 0.05). After 48 h of maternal refeeding, all values had returned to near control values for both groups (glucose group IGF-I: maternal, −5.2 ± 3.86; fetal, 0.01 ± 2.2 nmol/L; amino acid group: maternal, −11.66 ± 3.2; fetal, −0.70 ± 2.61 nmol/L). We conclude that in the ovine fetus glucose may have a more important role than amino acids in the regulation of fetal plasma IGF-I.
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Oliver, M., Harding, J., Breier, B. et al. Glucose but Not a Mixed Amino Acid Infusion Regulates Plasma Insulin-Like Growth Factor-I Concentrations in Fetal Sheep. Pediatr Res 34, 62–65 (1993). https://doi.org/10.1203/00006450-199307000-00015
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DOI: https://doi.org/10.1203/00006450-199307000-00015
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