Abstract
CNS is one of the target organs in children with HIV infection. The aims of this work were to correlate the clinical-neurologic signs with CCT findings in symptomatic HIV+children and to establish the predictive value of both parameters. Thirty eight patients infected with the human immunodeficiency virus and without specific treatment were evaluated (age range:4 months to 8 years). Six patients had no abnormal neurological signs. They were the negative control group and their CCT were normal. Out of 32 patients with signs of neurologic injury, 28(87%) had pathologic CCT. Twelve out of these 28 patients died (43%). The CCT findings were:(A) Cerebral atrophy (Cortical and/or central)=10/28 cases (35%);(B)Calcifica-tions of basal ganglia + (A)=5/28 cases (18%);(C) Low density of white matter=3/28 cases (11%);(D) Damage secondary to opportunistic infection=4/28 cases (14%) (Histoplasrrosis;Toxoplasmosis;Chagas Disease and Pneumococcal meningitis) and (E)Associated pathology findings=7/28 cases(25%) (Congenital infections;Congenital Hydrocephalus and Battered Child). The remaining four CCT=4/32 cases (13%)were normal and correponded to patients with Static Encephalopathy; they were 3 to 5 years old. We conclude that:a)The main CCT findings were cerebral atrophy and calcifications of basal ganglia; b)We did not find any primary CNS lymphoma;c)Neurological signs were found prior to CCT abnormalities;d)CCT pathologic findings were associated to poor diagnosis.
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Czomyj, L., Meli, F. & Fejerman, N. CENTRAL NERVOUS SYSTEM (CNS) INVOLVEMENT IN CHILDREN WITH HIV INFECTION CEREBRAL COMPUTED TOMOGRAPHY (CCT) FINDINGS.. Pediatr Res 33, 663 (1993). https://doi.org/10.1203/00006450-199306000-00053
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DOI: https://doi.org/10.1203/00006450-199306000-00053